Gutiérrez Gómez, EdgarLigarda Samanez, Carlos A.Choque Quispe, DavidMoscoso Moscoso, ElibetPalomino Rincón, HenryTaipe Pardo, FredyAguirre Landa, John PeterArévalo Quijano, José C.Muñoz Saenz, Jenny C.Quispe Quezada, Uriel RigobertoHuamán Carrión, Mary L.Sucari León, ReynaldoLuciano Alipio, RoberMuñoz Saenz, Judy M.Guzmán Gutiérrez, Rodrigo J.2026-04-162026-04-162023https://doi.org/10.3390/molecules28134961https://hdl.handle.net/20.500.14388/129Native potato clones grown in Peru contain bioactive compounds beneficial to human health. This study aimed to optimize the spray-drying nanoencapsulation of native potato phenolic extracts utilizing a central composite design and response surface methodology, obtaining the optimal treatment to an inlet temperature of 120 °C and an airflow of 141 L/h in the nano spray dryer B-90, which allowed maximizing the yield of encapsulation, antioxidant capacity (DPPH), encapsulation efficiency (EE), total phenolic compounds, and total flavonoids; on the other hand, it allowed minimizing hygroscopicity, water activity (Aw), and moisture. Instrumental characterization of the nanocapsules was also carried out, observing a gain in lightness, reddening of the color, and spherical nanoparticles of heterogeneous size (133.09–165.13 nm) with a negative ζ potential. Thermal, infrared, and morphological analyses confirmed the encapsulation of the core in the wall materials. Furthermore, an in vitro release study of phenolic compounds in an aqueous solution achieved a maximum value of 9.86 mg GAE/g after 12 h. Finally, the obtained nanocapsules could be used in the food and pharmaceutical industry.enghttps://purl.org/coar/access_right/c_abf2OptimizationResponse surfaceCentral composite rotatable designBioactive compoundsAntioxidant capacityinfo:eu-repo/semantics/article